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ea0056oc8.3 | MicroRNAs as biomarkers in endocrine diseases | ECE2018

Circulating levels of microRNAs associate with blood pressure and left ventricular mass in primary hypertensive patients

van Kralingen J.C. , Larsen C.K. , Connell J.M. , Freel E.M. , Zennaro M.C. , MacKenzie S.M. , Davies E.

Introduction: MicroRNA (miRNA) has been shown to post-transcriptionally regulate physiological systems modulating blood pressure, including the adrenal biosynthesis of aldosterone. This raises the possibility that levels of specific miRNAs circulating in plasma might reflect these functional effects and have diagnostic value in the identification of hypertension and its various underlying causes. In a previous study, we measured plasma levels of miRNAs originating from the miR...

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ea0011p379 | Diabetes, metabolism and cardiovascular | ECE2006

Chromosome 1p shows significant linkage to steroid metabolism in hypertension in the British Genetics of Hypertension Study

Padmanabhan S , Fraser R , Ingram M , Davies E , Munroe PB , Dobson R , Brown M , Samani N , Clayton D , Farrall M , Webster J , Lathop M , Caulfield M , Dominczak AF , Connell JM

Background: Glucorticoids can affect blood pressure in humans, as demonstrated most strikingly in Cushings syndrome. We have previously reported that total cortisol metabolite excretion is raised in obese subjects, while other investigations have identified genetically determined changes in glucocorticoid receptor function as contributors to hypertension. Furthermore, in essential hypertension, vasoconstrictor sensitivity to glucocorticoids is increased. Such raised sens...

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Endocrine Abstracts

Circulating levels of microRNAs associate with blood pressure and left ventricular mass in primary hypertensive patients

Chromosome 1p shows significant linkage to steroid metabolism in hypertension in the British Genetics of Hypertension Study

BiosciAbstracts